Work

Author response: Hemozoin produced by mammals confers heme tolerance

Year: 2019

Type: peer-review

Abstract: Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.

Source: eLife

DOI: 10.7554/elife.49503.sa2

Authors: Rini H Pek, Xiaojing Yuan, Nicole Rietzschel, Jianbing Zhang, Laurie Jackson, Eiji Nishibori, Ana Ribeiro, William Simmons, Jaya Jagadeesh, Hiroshi Sugimoto, Md Zahidul Alam, Lisa Garrett, Malay Haldar, Martina Ralle, John D Phillips, David M Bodine, Iqbal Hamza

Institutions: University of Maryland, College Park, University of Utah, University of Tsukuba, Tsukuba Research Center for Energy Materials Science, National Institutes of Health, National Human Genome Research Institute, SPring-8, RIKEN, University of Pennsylvania, Oregon Health & Science University

Language: English

Topic: Heme Oxygenase-1 and Carbon Monoxide

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4246508850

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