Work

Deuteration of indole and N-methylindole by Raney nickel catalysis

Year: 1999

Type: article

Abstract: Indole and N-methylindole have been partially or fully deuterated by Raney nickel catalyzed 1H-2H exchange in a series of deuterated solvents. Perdeuterated indoles have been obtained in water and methanol while compounds that are preferentially deuterated at specific sites were obtained in chloroform, acetone, acetonitrile, ethanol, and isopropanol. The partially deuterated compounds are an important research tool for solid-state NMR studies on proteins. Copyright © 1999 John Wiley & Sons, Ltd.

Source: Journal of Labelled Compounds and Radiopharmaceuticals

DOI: 10.1002/(sici)1099-1344(199907)42:7<709::aid-jlcr235>3.0.co;2-2

Authors: Wai-Ming Yau, Klaus Gawrisch

Institutions: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W1978622520

FWCI: 0.352

Cites:

Cited by: 28

Related to: 10