Work

Paget disease of bone

Year: 2005

Type: article

Abstract: Paget disease of bone (PD) is characterized by excessive bone resorption in focal areas followed by abundant new bone formation, with eventual replacement of the normal bone marrow by vascular and fibrous tissue. The etiology of PD is not well understood, but one PD-linked gene and several other susceptibility loci have been identified, and paramyxoviral gene products have been detected in pagetic osteoclasts. In this review, the pathophysiology of PD and evidence for both a genetic and a viral etiology for PD will be discussed.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci200524281

Authors: G. David Roodman, Jolene J. Windle

Institutions: VA Pittsburgh Healthcare System, University of Pittsburgh Medical Center, Virginia Commonwealth University

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, VA Pittsburgh Healthcare System, National Institute of Arthritis and Musculoskeletal and Skin Diseases