Work

Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System

Year: 2021

Type: article

Abstract: (Stem Cell Reports 14, 1033–1043; June 9, 2020) In the original version of our article, Dr. David S. Lorberbaum was unintentionally omitted from the author list. This has now been corrected in the online version of our manuscript and Dr. Lorberbaum has been added as a co-author for his contributions on data analysis and quantification in Figure 1. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation SystemHudish et al.Stem Cell ReportsMay 7, 2020In BriefRuss and colleagues present here a rapid, scalable, suspension-culture system for the efficient generation of functional human motor neurons from pluripotent stem cells. Using a soma and neurite fractionation approach, they reveal that mitochondrial transcripts, but not proteins, are neurite enriched under conditions modeling diabetic neuropathies. These findings suggest mRNA mis-localizations as a potential novel disease mechanism in motor neurons. Full-Text PDF Open Access

Source: Stem Cell Reports

DOI: 10.1016/j.stemcr.2021.03.006