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Variation in PNPLA3 is associated with outcomes in alcoholic liver disease

Year: 2009

Type: preprint

Abstract: Two recent genome-wide association studies have described associations of SNP variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels in population based cohorts. We investigated the contributions of these variants to clinical outcomes in Mestizo subjects with a history of excessive alcohol consumption. We show that non-synonymous variant rs738409[G] (I148M) in PNPLA3 is strongly associated with alcoholic liver disease and progression to alcoholic cirrhosis (unadjusted OR = 2.25, P = 1.7x10^-10^; ancestry-adjusted OR = 1.79, P = 1.9x10^-5^).

Source: Nature Precedings

DOI: 10.1038/npre.2009.3254.1

Authors: Chao Tian, Renee Stokowski, David Kershenobich, Dennis Ballinger, David Hinds

Institutions: Perlegen (United States), Universidad Nacional Autónoma de México, Complete Genomics (United States)

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4248099455

Cites: 1

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Related to: 10