Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics
Year: 2019
Type: article
Abstract: Ann Oncol 2018; 29(11): 2192–2199 (doi: 10.1093/annonc/mdy412) Figure 1B has been corrected to display as follows: The Publisher apologizes for the error. Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeuticsAnnals of OncologyVol. 29Issue 11PreviewMetastatic basal cell carcinoma is an ultra-rare manifestation of a common disease, appearing in 0.0028%–0.5% of basal cell carcinomas. Initial therapeutic efforts focused on cytotoxic chemotherapy administration. However, it is now known that the Hedgehog signaling pathway is crucial for basal cell proliferation and Hedgehog pathway mutations may lead to tumorigenesis; thus, small-molecule inhibitors of alterations in the components of this pathway, including smoothened (SMO) and GLI, have been the focus of recent therapeutic developments. Full-Text PDF Open Archive
Source: Annals of Oncology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,250
OpenAlex ID: W4248195730