Work

Heart valve function: a biomechanical perspective

Year: 2008

Type: article

Abstract: Heart valve function: a biomechanical perspectiveThe results presented and described in figures 2 and 3 are based on a sophisticated three-dimensional computational fluid dynamics (CFD) model developed by Dr Fotis Sotiropoulos and Dr Liang Ge at the University of Minnesota.These early results, as described in the article, are those obtained by them and are the first numerical simulations to describe the differences in shear stress patterns on the ventricular and aortic surfaces and qualitatively agree with in vitro (Weston et al. 1999) and in vivo (Simmons et al. 2005) experimental observations.The CFD model is the curvilinear immersed boundary (CURVIB) method of Ge & Sotiropoulos [ J. Comp.Phys.225(2), 1782-1809, 2007], which is capable of performing high-resolution simulations of heart valve haemodynamics at physiological conditions.The kinematics of the leaflets were prescribed as input to the CFD model and were obtained from the experimental measurements performed in Dr Yoganathan's laboratory (Leo et al. 2006) and a tissue deformation model developed by

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2008.0062

Authors: Michael S Sacks, Ajit P Yoganathan

Institutions: University of Pittsburgh, McGowan Institute for Regenerative Medicine, Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Science Foundation, Georgia Institute of Technology

Awards: G2504929560, ERC: Research Center for the Engineering of Living Tissues