Year: 2015
Type: article
Study design: Observational Study
Abstract: Background: Down syndrome (DS) is a most common cause of mental retardation in humans.Monitoring genetic damage in DS individuals helps in evaluating genetic damage.Micronucleus assay is potentially an excellent tool to serve as a biomarker which detects chromosomal loss or malfunction.Aim of the study: The objective of the study is to evaluate micronuclei (MN) frequency in exfoliated buccal cells in DS individuals.Materials and Methods: The study subjects consisted of clinically diagnosed cases of Down syndrome.Healthy subjects without any medical conditions formed the control group.The cyto-smears were stained with Papanicolaou stain.Results and Conclusion: The presence of increased number of micronuclei in Down syndrome (P<0.05)patients may be useful in identifying individuals with increase risk of mental retardation.
DOI: 10.5866/2015.7.10032
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4248950870