Work

Telomere Diseases

Year: 2009

Type: review

Abstract: The Nobel Prize in Physiology or Medicine 2009 was recently awarded to three scientists for their work on telomeres, which are repetitive DNA structures at the tips of chromosomes, and the enzyme telomerase. Telomeres protect the genome from loss of genetic material. This review recounts the medical implications of telomeres and focuses on a group of diseases in which the loss of telomeres appears to be causal.

Source: New England Journal of Medicine

DOI: 10.1056/nejmra0903373

Authors: Rodrigo T. Calado, Neal S. Young

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health