CLIC4 and Schnurri-2: A dynamic duo in TGFβ signaling with broader implications in cellular homeostasis and disease
Year: 2010
Type: article
Abstract: CLIC4 is a highly conserved, multifunctional member of the chloride intracellular channel family of proteins. The protein is largely cytoplasmic but translocates to the nucleus upon a variety of stimuli including TGF-β, TNF-α and etoposide. Nuclear resident CLIC4 causes growth arrest, terminal differentiation and apoptosis. Recently, it was discovered that TGF-β causes CLIC4 to associate with Schnurri-2 and together they translocate to the nucleus and dissociate thereafter. The nuclear function of CLIC4 was further illuminated by the discovery that CLIC4 enhances TGF-β signaling by associating with phospho-Smad2 and 3 and preventing their dephosphorylation. Enhanced TGF-β dependent gene expression and growth inhibition are downstream consequences of this activity of CLIC4. In this article, we speculate on other consequences of the CLIC4 relation to TGF-β signaling and the potential for CLIC4 to participate in other cellular functions related to normal homeostasis and disease.
Source: Nucleus
DOI: 10.4161/nucl.10920
Authors: Anjali Shukla, Stuart H. Yuspa
Institutions: National Institutes of Health, National Cancer Institute
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4249779881