Work

Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas

Year: 1996

Type: article

Abstract: Mutational analysis of the p16/CDKN2 gene was conducted by direct sequencing of the whole coding sequence (exons 1-3 and flanking splicing sites) in 21 esophageal squamous-cell carcinomas and 3 adenocarcinomas from a high-incidence area of Italy. Two inactivating mutations were found in exon 1 of the gene (both in squamous-cell carcinoma), whereas no mutations were detected in exon 2, where most of the sequence changes reported so far have been located, or in exon 3. Southern blot analysis of exon 2 in this set of samples and in a complementary set of 12 tumor samples from France did not show homozygous deletions or detectable gene rearrangements. Thus, p16/CDKN2 gene alterations do not appear to play a major role in the group of patients examined.

Source: International Journal of Cancer

DOI: 10.1002/(sici)1097-0215(19960503)66:3<301::aid-ijc5>3.0.co;2-2

Authors: Asunción Esteve, Ghyslaine Martel-Planche, Bakary S. Sylla, Monica Hollstein, Pierre Hainaut, Ruggero Montesano

Institutions: Centre international de recherche sur le cancer, German Cancer Research Center

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,030