Work

Rho GTPases

Year: 1998

Type: review

Abstract: The mammalian Rho GTPase family currently consists of seven distinct proteins: Rho (A, B, and C isoforms), Rac (1 and 2 isoforms), Cdc42 (Cdc42Hs and G25K isoforms), RhoD, RhoG, RhoE, and TC10. Like other members of the Ras superfamily, Rho proteins act as molecular switches to control cellular processes by cycling between active, GTP-bound and inactive, GDP-bound states (Fig.1). Activation of the GTPase, through GDP-GTP exchange, is promoted by guanine nucleotide exchange factors (GEFs),1 whereas inactivation (by an intrinsic GTPase activity) is stimulated by GTPase-activating proteins (GAPs).

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.273.33.20685

Authors: Deborah J.G. Mackay, Alan Hall

Institutions: MRC Laboratory for Molecular Cell Biology, University College London, Medical Research Council

Language: Spanish

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: Wellcome Trust