Work

Author response: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

Year: 2016

Type: peer-review

Abstract: Genetic and molecular analysis of TP53 exon-6 truncating mutations reveal that these mutations, contrary to current belief, promote tumorigenesis and point towards strategies for treating cancers driven by these prevalent mutations.

DOI: 10.7554/elife.17929.068

Authors: Nitin H Shirole, Debjani Pal, Edward R Kastenhuber, Serif Senturk, Joseph Boroda, Paola Pisterzi, Madison Miller, Gustavo Munoz, Marko Anderluh, Marc Ladanyi, Scott W Lowe, Raffaella Sordella

Institutions: Cold Spring Harbor Laboratory, Stony Brook University, Memorial Sloan Kettering Cancer Center, University of Ljubljana

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4250728755

Cites:

Cited by: 2

Related to: 10