Work

Author response: Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Year: 2017

Type: peer-review

Abstract: Proteomics and functional genomics coupled to an antibody discovery pipeline revealed the influence of oncogenic RAS signaling on the cell-surface proteome and resulted in the discovery of potential therapeutic targets for RAS-driven cancers.

DOI: 10.7554/elife.31098.027

Authors: Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells

Institutions: University of California, San Francisco, Howard Hughes Medical Institute, Frederick National Laboratory for Cancer Research, UCSF Helen Diller Family Comprehensive Cancer Center

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4251729013

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