Work

Faculty Opinions recommendation of Nucleoid Size Scaling and Intracellular Organization of Translation across Bacteria.

Year: 2019

Type: peer-review

Abstract: The scaling of organelles with cell size is thought to be exclusive to eukaryotes.Here, we demonstrate that similar scaling relationships hold for the bacterial nucleoid.Despite the absence of a nuclear membrane, nucleoid size strongly correlates with cell size, independent of changes in DNA amount and across various nutrient conditions.This correlation is observed in diverse bacteria, revealing a near-constant ratio between nucleoid and cell size for a given species.As in eukaryotes, the nucleocytoplasmic ratio in bacteria varies greatly among species.This spectrum of nucleocytoplasmic ratios is independent of genome size, and instead appears linked to the average

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.735847258.793561899

Author: Jan M Skotheim

Institution: Stanford University

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, Belgian American Educational Foundation, Yale University, National Institutes of Health

Awards: G2294964640, G9000102301, G9000191267

OpenAlex ID: W4251791472

Cites: 110

Cited by:

Related to: 10