Year: 2021
Type: article
Abstract: Irons, as the most abundant transition metal in living system, play an irreplaceable role in many physiological and pathological processes.The misregulation of Fe 2＋ homeostasis not only affects the occurence and delelopment of various diseases, such as cancer, cardiovascular disease and neurodegenerative disorders, but also induces ferroptosis.Although two forms of iron (Fe 2＋ and Fe 3＋ ) exist in cells, reducing microenvironment of cells makes it exist mainly in the form of Fe 2＋ .Therefore, developing a sensitive approach for Fe 2＋ is particularly important because it may contribute to the in-depth understanding of the relationship between Fe 2＋ and human health and disease.In recent years, with the rapid development of fluorescent imaging technique, fluorescent probes for the sensitive detection of Fe 2＋ have attracted great interest.Fe 2＋ fluorescent probes reported in the last ten years are summarized, according to probes design, sensing mechanisms with Fe 2＋ , optical properties and biological application.In addition, the development prospect of Fe 2＋ fluorescent probes is predicted.
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funder: Shanxi Medical University
OpenAlex ID: W4251844753