Modeling ALS and FTLD proteinopathies in yeast: An efficient approach for studying protein aggregation and toxicity
Year: 2011
Type: article
Abstract: In recent years there have been several reports of human neurodegenerative diseases that involve protein misfolding being modeled in the yeast Saccharomyces cerevisiae. This review summarizes recent advances in understanding the specific mechanisms underlying intracellular neuronal pathology during Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), including SOD1, TDP-43 and FUS protein inclusions and the potential of these proteins to be involved in pathogenic prion-like mechanisms. More specifically, we focus on findings from yeast systems that offer tremendous possibilities for screening for genetic and chemical modifiers of disease-related proteotoxicity.
Source: Prion
DOI: 10.4161/pri.17229
Authors: Dmitry Kryndushkin, Frank Shewmaker
Institution: Uniformed Services University of the Health Sciences
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1992788111