Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
Year: 2021
Type: article
Study design: Observational Study
Abstract: The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications of microstructure, and we quantified volume loss in GM in a cohort of patients with MS classified into three groups according to disease duration. Additionally, we investigated the relationship between GM changes with disease severity. We studied 54 healthy controls and 247 MS patients classified regarding disease duration: MS1 (less than 5 years, n = 67); MS2 (5-15 years, n = 107); and MS3 (more than15 years, n = 73). We compared GM mean diffusivity (MD), fractional anisotropy (FA) and volume between groups, and estimated their clinical associations. Regional modifications in diffusion measures (MD and FA) and volume did not overlap early in the disease, and became widespread in later phases. We found higher MD in MS1 group, mainly in the temporal cortex, and volume reduction in deep GM and left precuneus. Additional MD changes were evident in cingulate and occipital cortices in the MS2 group, coupled to volume reductions in deep GM and parietal and frontal poles. Changes in MD and volume extended to more than 80% of regions in MS3 group. Conversely, increments in FA, with very low effect size, were observed in the parietal cortex and thalamus in MS1 and MS2 groups, and extended to the frontal lobe in the later group. MD and GM changes were associated with white matter lesion load and with physical and cognitive disability. Microstructural integrity loss and atrophy present differential spatial predominance early in MS and accrual over time, probably due to distinct pathogenic mechanisms that underlie tissue damage.
Source: Scientific Reports
Authors: Elisabeth Solana, Eloy Martinez-Heras, Victor Montal, Eduard Vilaplana, Elisabet Lopez-Soley, Joaquim Radua, Nuria Sola-Valls, Carmen Montejo, Yolanda Blanco, Irene Pulido-Valdeolivas, Maria Sepúlveda, Magi Andorra, Joan Berenguer, Pablo Villoslada, E. H. Martinez-Lapiscina, Ferran Prados, Albert Saiz, Juan Fortea, Sara Llufriu
Institutions: Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Universitat Autònoma de Barcelona, Hospital de Sant Pau, Biomedical Research Networking Center on Neurodegenerative Diseases, King's College London, Karolinska Institutet, Centro de Investigación Biomédica en Red de Salud Mental, Universitat Oberta de Catalunya, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, University College London
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,990
Funders: Teva Pharmaceutical Industries, Fundació la Marató de TV3, Ministerio de Ciencia, Innovación y Universidades, Centres de Recerca de Catalunya, Generalitat de Catalunya, Universitat de Barcelona, Red Española de Esclerosis Múltiple, Fundació Víctor Grífols i Lucas, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, National Institutes of Health, Instituto de Salud Carlos III, European Regional Development Fund, National Institute on Aging
Awards: G1122758695, G1686209703, G1853423388, The Role of Inflammation and NGF Dysfunction in the Evolution of AlzheimerDisease Pathology in Down syndrome, Biomarcadores de resonancia magnética avanzada en esclerosis múltiple: asociación con el perfil clínico evolutivo y sustrato genético, La estructura cerebral y el metabolismo en la enfermedad de Alzheimer preclínica. Interacciones entre nuevos y viejos biomarcadores, G2372186262, G2463419661, G2478185652, G2677554862, G2771999017, G2882112756, Rehabilitación cognitiva y plasticidad cerebral en la Esclerosis Múltiple: en búsqueda de la evidencia., G3165597566, G3168399588, G3295560047, G3349265605, G3434578777, G3435010205, G3470407348, G3559709381, G3569722079, G3884839443, G3924501560, G3965561686, G400519789, G4111453737, G4141902598, G4146428912, G4193446334, G4350442709, G4484208813, G5014579882, G5269258838, G5813809628, G5935723808, Estudios longitudinales de RM magnética estructural, de difusión y funcional en la enfermedad de Alzheimer preclínica esporádica y asociada al síndrome de Down, G6310513242, G6368058359, G6441261293, G6507690662, G6523755466, G6555716666, G6606458654, G6814216392, Hacia biomarcadores robustos en salud mental: Creación de un atlas de los trastornos mentales basado en la resonancia magnética, y validación inicial de una herramienta asociada de ayuda diagnóstica, Via visual aferente: innovación para trastorno del Sueño REM y Parkinson, G719011463, G7262937411, Estudio del daño axonal en Esclerosis Múltiple mediante estudios de neuroimagen de la vía óptica, G7504244916, Tau pathology in Down syndrome and Alzheimer's, G7994548261, G8284279906, G8391690769, Biological Correlates of Alzheimer in Down Syndrome., G8486608010, G8600537192, G8947099571
OpenAlex ID: W3165764836