Work

Faculty Opinions recommendation of The dTAG system for immediate and target-specific protein degradation.

Year: 2019

Type: peer-review

Abstract: Dissecting complex biological systems requires target-specific control of protein function or abundance.Genetic perturbations are limited by off-target effects, multi-component complexity, and irreversibility.Most limiting is the requisite delay from modulation to experimental measurement.To enable the immediate and selective control of single protein abundance, we created a chemical biology system that leverages the potency of cell-permeable heterobifunctional degraders.The dTAG system pairs a novel degrader of FKBP12 F36V with expression of

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.732899543.793558654

Author: Songon An

Institution: University of Maryland, Baltimore County

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Damon Runyon Cancer Research Foundation

Award: G4021786115

OpenAlex ID: W4252075743

Cites: 52

Cited by:

Related to: 10