Work

Author response: Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Year: 2016

Type: peer-review

Abstract: Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.

DOI: 10.7554/elife.12792.038

Authors: Sean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, Kathryn E Carlson, Teresa A Martin, Scott J Novick, Weiyi Toy, Bradley Green, Srinivas Panchamukhi, Benita S Katzenellenbogen, Emad Tajkhorshid, Patrick R Griffin, Yang Shen, Sarat Chandarlapaty, John A Katzenellenbogen, Geoffrey L Greene

Institutions: University of Chicago, University of Illinois Urbana-Champaign, Scripps Research Institute, Memorial Sloan Kettering Cancer Center, Texas A&M University

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4252089129

Cites:

Cited by: 3

Related to: 10