Work

Ideation and Assessment of a Novel Nitric Oxide Delivery System for Spontaneously Breathing Subjects

Year: 2021

Type: conference-abstract

Abstract: Rationale High dose nitric oxide (NO) produces broad antimicrobial activity and several clinical trials are now testing the efficacy of NO inhalation on patients infected by SARS CoV-2.Nitrogen dioxide (NO 2 ) is formed by the reaction between NO and oxygen, and when combined with water in the airways, NO 2 , forms nitric acid, leading to a caustic burn of the airways.In this study, we designed and developed a breathing system capable of safely delivering high concentrations of NO.Methods We developed a gas delivery system that utilizes standard respiratory circuit connectors, a reservoir bag, and a scavenging chamber containing calcium hydroxide (Ca(OH) 2 ) (Fig. 1).

Source: American Journal of Respiratory and Critical Care Medicine

DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3609

Authors: S. Gianni, C.C. Araujo Morais, G. Larson, R. Pinciroli, R.W. Carroll, B. Yu, W.M. Zapol, L. Berra

Institution: Massachusetts General Hospital

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4252331717

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