Mp61-15 Urologic Complications Requiring Intervention Following High-dose Pelvic Radiation for Cervical Cancer
Year: 2019
Type: article
Study design: Observational Study
Abstract: You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Ureter (including Pyeloplasty) and Bladder Reconstruction (including fistula), Augmentation, Substitution, Diversion II (MP61)1 Apr 2019MP61-15 UROLOGIC COMPLICATIONS REQUIRING INTERVENTION FOLLOWING HIGH-DOSE PELVIC RADIATION FOR CERVICAL CANCER Haerin Lee*, Jacqueline Zillioux, David Rapp, Tracey Krupski, Linda Duska, Timothy Showalter, Jennifer Lobo, and Noah Schenkman Haerin Lee*Haerin Lee* More articles by this author , Jacqueline ZilliouxJacqueline Zillioux More articles by this author , David RappDavid Rapp More articles by this author , Tracey KrupskiTracey Krupski More articles by this author , Linda DuskaLinda Duska More articles by this author , Timothy ShowalterTimothy Showalter More articles by this author , Jennifer LoboJennifer Lobo More articles by this author , and Noah SchenkmanNoah Schenkman More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556817.33231.93AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Significant variation exists in the reported rates of urologic complications following XRT for cervical cancer, with most literature being over 20 years old. We sought to define the modern incidence of radiation-induced complications requiring procedural intervention (RICP) following high-dose radiotherapy for cervical carcinoma. METHODS: We performed a retrospective chart review of cervical cancer patients undergoing radiotherapy (XRT). Chart review was performed with primary focus on post-XRT urologic complications requiring procedural intervention (Clavien ≥III). Data regarding urological complications was then collected, including Clavien grade, XRT dose, procedure performed, timing of complication, and need for additional procedures. Univariate and multivariate logistic regression models were performed to assess predictive value of demographic and clinical variables for RICP. RESULTS: A total of 134 patients with FIGO stage 1A2-4B cervical cancer were included in study analysis, with 26 patients experiencing RICP (RICP complication rate of 19.4%). Patient complications and resultant urologic procedures are detailed in Table 1. A total of 37 RICP were identified, representing 1.4 RICP/patient. The most common complications were ureteral stricture and radiation cystitis. The most common procedures performed in the treatment of these complications were ureteral stenting, percutaneous nephrostomy tube placement, and bladder fulguration. Notably, a total of 231 procedures were performed in the treatment of RICP, representing 8.9 procedures/patient. Logistic regression demonstrated active smoking, abdominal surgery following radiation, and radiation dose to be predictors of RICP. CONCLUSIONS: XRT in the treatment of cervical cancer is associated with a high rate of RICP. Further, these complications often require numerous procedures and long-term management given their complexity. Source of Funding: none Charlottesville, VA© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e883-e883 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Haerin Lee* More articles by this author Jacqueline Zillioux More articles by this author David Rapp More articles by this author Tracey Krupski More articles by this author Linda Duska More articles by this author Timothy Showalter More articles by this author Jennifer Lobo More articles by this author Noah Schenkman More articles by this author Expand All Advertisement PDF downloadLoading ...
Source: The Journal of Urology
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4252404729