Year: 2011
Type: article
Abstract: Avoiding TENCarbamazepine has a number of uses.It blocks epileptic seizures.It stabilises mood swings caused by bipolar disorder and relieves some of the suffering associated with trigeminal neuralgia.Other offlabel uses are proliferating.Unfortunately, a few individuals who take this drug experience Stevens -Johnson syndrome (SJS) or the related disease, toxic epidermal necrolysis (TEN).The likelihood of developing one of these potentially deadly adverse effects has been linked to the HLA B*1502 allele.Recently, a group of clinicians tested the hypothesis that by screening for HLA B*1502 they could profoundly decrease the prevalence of SJS-TEN in the carbamazepine treatment population.Almost 8 per cent of 5,000 patients who were candidates for carbamazepine therapy tested positive for HLA B*1502 and were prescribed something else.The remainder received carbamazepine, and not one case of SJS-TEN was observed.Score another point for pharmacogenetic screening.
Source: Human Genomics
Author: Robert I. Scheinman
Institution: University of Colorado Anschutz
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,290
OpenAlex ID: W4252680517