Work

Faculty Opinions recommendation of β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.

Year: 2020

Type: peer-review

Abstract: Small molecule neurotensin receptor 1 (NTSR1) agonists have been pursued for more than 40 years as potential therapeutics for psychiatric disorders, including drug addiction.Clinical development of NTSR1 agonists has, however, been precluded by their severe side effects.NTSR1, a G protein-coupled receptor (GPCR), signals through the canonical activation of G

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.738029959.793575371

Author: Arun Shukla

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: New York Community Trust, North Carolina Biotechnology Center, Long Island Community Foundation

Award: G8379456544

OpenAlex ID: W4252727317

Cites: 68

Cited by:

Related to: 10