Work

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein

Year: 2001

Type: article

Abstract: MethodsAnimal models.Transgenic (TG) mice expressing Csx/Nkx2.5(I183P)or wild-type Csx/Nkx2.5 in the heart were created as follows.A cDNA encoding a FLAGtagged Csx/Nkx2.5(I183P)or Csx/Nkx2.5 in pMALC2 was digested with SacI and EcoRI, blunt ended, and lig-

Source: Journal of Clinical Investigation

DOI: 10.1172/jci200112694

Authors: Hideko Kasahara, Hiroko Wakimoto, Margaret Liu, Colin T. Maguire, Kimber L. Converso, Tetsuo Shioi, Weei-Yuarn Huang, Warren J. Manning, David Paul, Joel Lawitts, Charles I. Berul, Seigo Izumo

Institutions: Beth Israel Deaconess Medical Center, Boston Children's Hospital, Harvard University, University of Michigan

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, Charles H. Hood Foundation, National Institutes of Health

OpenAlex ID: W4252828767

FWCI: 1.359

Cites: 35

Cited by: 18

Related to: 10