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[O3–03–03]: TAU PATHOLOGY AND GRAY MATTER ATROPHY CONTRIBUTE TO COGNITIVE IMPAIRMENT IN ALZHEIMER's DISEASE

Year: 2017

Type: article

Abstract: and executive function and cluster 4 (N¼14), who had impairment across all 4 domains, manifested neurodegeneration (MRI>FDG) throughout the brain.All clusters showed global amyloid burden (Figure 3).Conclusions: We identified several cognitive clusters among amnestic EOAD ADNI subjects.In addition to the pure amnestic and globally impaired variants, we also found a visuospatial and a language/executive variant suggesting phenotypic heterogeneity in this rare form of AD.The pattern of atrophy and hypometabolism in each cluster was in agreement with the observed cognitive phenotype.

Source: Alzheimer s & Dementia

DOI: 10.1016/j.jalz.2017.07.316

Authors: Alexandre Bejanin, Daniel R. Schonhaut, Renaud La Joie, Joel H. Kramer, Suzanne L. Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P. O'Neil, Marilu Gorno‐Tempini, Zachary A. Miller, Howard J. Rosen, Bruce L. Miller, William J. Jagust, Gil D. Rabinovici

Institutions: Lawrence Berkeley National Laboratory, Inserm, University of California, San Francisco, University of California, Berkeley, Université de Caen Normandie

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4252991778

FWCI:

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