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Cooperation between Noncanonical Ras Network Mutations

Year: 2015

Type: article

Abstract: (Cell Reports 10, 307–316; January 15, 2015) In the original published version of this paper, Paul C. Trampont was not marked as a co-first author. This error has been corrected, and the correct affiliations now appear with this paper online. Cell Reports apologizes for this error. Cooperation between Noncanonical Ras Network MutationsStites et al.Cell ReportsJanuary 15, 2015In BriefStites et al. use a mathematical model to investigate combinations of mutations in the Ras pathway. The model predicts synergy between specific combinations of mutations, and this prediction is supported by experiments. Mining human cancer genome databases finds increased co-occurrence of Ras pathway mutations, consistent with the model analysis. Full-Text PDF Open Access

Source: Cell Reports

DOI: 10.1016/j.celrep.2015.01.048

Authors: Edward C. Stites, Paul C. Trampont, Lisa B. Haney, Scott F. Walk, Kodi S. Ravichandran

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620

OpenAlex ID: W4253000801

FWCI: 0.118

Cites:

Cited by: 8

Related to: 10