Synthesis, Characterization of 3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline and Its Crystal Structure
Year: 2014
Type: article
Abstract: 3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline (I), an important intermediate to synthesize pitavastatin calcium. It was prepared from ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate via reduction by KBH4/ZnCl2 and then bromide by PBr3. The product was characterized by NMR and LC-MS. The crystal structure of compound I was investigated using X-ray diffraction and SHELXTL-97 software. The result indicated that compound I crystallized in the triclinic system, space group P-1 with a = 9.6150(19), b = 9.868 (2), c = 10.060(2) Å, V = 783.3 (4) Å3; Z 2.
Source: Asian Journal of Chemistry
Authors: Jia-Ying Xu, Wei-Hua Cheng, Lan Wang, Jian-Guo Wu, Kai Wang
Institutions: Yancheng Institute of Technology, Nanjing University
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
Funders: Changzhou University, Nanjing University
OpenAlex ID: W4253108053