Work

Faculty Opinions recommendation of The Top1 paradox: Friend and foe of the eukaryotic genome.

Year: 2019

Type: peer-review

Abstract: Topoisomerases manage the torsional stress associated with the separation of DNA strands during transcription and DNA replication.Eukaryotic Topoisomerase I (Top1) is a Type IB enzyme that nicks and rejoins only one strand of duplex DNA, and it is especially important during transcription.By resolving transcription-associated torsional stress, Top1 reduces the accumulation of genome-destabilizing R-loops and non-B DNA structures.The DNA nicking activity of Top1, however, can also initiate genome instability in the form of illegitimate recombination, homologous recombination and mutagenesis.In this review, we focus on the diverse, and often opposing, roles of Top1 in regulating eukaryotic genome stability.

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.727745036.793565196

Author: Scott Kaufmann

Institution: Mayo Clinic

Language: English

Topic: Cancer therapeutics and mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Welch Foundation, National Institutes of Health, National Institute of General Medical Sciences

Awards: G566669221, G-Quadruplex forming sequence motifs and genome instability, G8418638008

OpenAlex ID: W4253157996

Cites: 114

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Related to: 10