Work

Faculty Opinions recommendation of Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo.

Year: 2019

Type: peer-review

Abstract: Schaks et al. use gene disruptioncombined with re-expression of point mutants of the Sra-1/PIR121 subunit of mammalian WRC or the PIR ortholog in Dictyostelium to unravel differential functions of the two Rac interaction surfaces on WRC in vivo.These functions are crucial to both lamellipod/pseudopod protrusion and cell-migration efficiency.

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.734360608.793559192

Author: Kenneth Campellone

Institution: University of Connecticut

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Cancer Research UK, Deutsche Forschungsgemeinschaft

Awards: G119271999, G1207113892, G4782105552, G497123119, G5600702830

OpenAlex ID: W4253279419

Cites: 46

Cited by:

Related to: 10