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Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche

Year: 2012

Type: article

Abstract: (Cell Reports 2, 964–975; October 25, 2012) In the original version of this article, published on October 18, the affiliation of Takahiro Ito and Tannishtha Reya was incorrectly written as “University of San Diego.” The correct affiliation is “University of California, San Diego,” which now appears here. In addition, attribution for the imaging technique described in the Results section was missing. The corrected text is as follows: “To determine the specific effect that anti-PTN administration had on the homing of transplanted HPCs, we performed intravital imaging using methods developed in the Reya lab (J.R.H. and T.R., unpublished data) to observe intravenously transplanted BM lin-GFP+ cells homing within the calvarial BM endothelium in dsRed mice.” The authors regret these errors. Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular NicheHimburg et al.Cell ReportsOctober 18, 2012In BriefMuch remains unknown regarding how the bone marrow (BM) microenvironment regulates hematopoietic stem cell (HSC) fate. Chute and colleagues demonstrate that BM endothelial cells secrete pleiotrophin (PTN), a heparin-binding growth factor, in the HSC niche. Mice lacking PTN contained decreased BM HSCs and a severe defect in hematopoietic regenerative capacity. Antibody blockade of PTN inhibited HSC homing to the niche and promoted HSC mobilization to the blood. Thus, PTN is a secreted component of the vascular niche that regulates HSC retention and self-renewal. Full-Text PDF Open Access

Source: Cell Reports

DOI: 10.1016/j.celrep.2012.11.005