Pleuropulmonary Blastoma Mimicking Lobar Pneumonia with DICER1 Gene Positive in a 3-Year-Old Child: A Case Report and Review of the Literature
Year: 2021
Type: article
Study design: Case Report
Abstract: Introduction: Pleuropulmonary blastoma is a very rare malignant tumor of the lung presenting in early childhood of less than 6 years. Case Presentation:A 3-years-old Saudi girl with a family history of malignancy presented with a history of a cough for one week and fever for 5 days.Radiological evaluation indicated a right lung mass.Thoracotomy and excisional biopsy showed a solid variant of pleuropulmonary blastoma.DICER1 gene was detected.Surgical treatment followed by chemotherapy resulted in disease clearance. Conclusion:To the best of our knowledge, this is the first reported pediatric case of DICER1 gene positive in our country.This case is reported to highlight the importance of attention to detailed history and early intervention in suspected cases.In the presence of persistent respiratory symptoms with heterogeneous lesions seen on chest imaging, the suspicion of malignant lung disease should be considered.Aggressive surgical resection and adjunctive chemotherapy can decrease progression in advanced disease.
Source: Acta Scientific Paediatrics
Institution: King Saud Medical City
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4253478745