Work

Concurrent application of blinatumomab and haploidentical donor leukocyte infusions for refractory primary mediastinal large B-cell lymphoma

Year: 2021

Type: article

Abstract: Primary mediastinal large B-cell lymphoma (PMBCL) is a rare hematologic malignancy with distinct clinical and immunopathological features. We report a case of a young adult male with disease refractory to multiple lines of therapy, including CAR-T cells, who achieved his first complete remission after haploidentical BMT, following donor leukocyte infusions (DLI) given concurrently with blinatumomab. While DLI has been used after T-replete haplo-BMT with PT-CY, there are no reports on its use for PMBCL. Similarly, blinatumomab is active against B-cell lymphomas, but literature is lacking in patients with PMBCL. Our experience illustrates that blinatumomab can be used concurrently with DLI in a haploidentical setting to achieve disease response in PMBCL. Despite our encouraging experience with this case, we would not recommend this approach outside of a clinical trial as blinatumomab may exacerbate the GvHD risks of DLI especially in a haploidentical setting.

Source: Therapeutic Advances in Hematology

DOI: 10.1177/2040620721994348

Authors: Jasmine Smith, Abhijeet Kumar, Natalie A. Stanton, Emmanuel Katsanis

Institutions: University of Arizona, Banner - University Medical Center Tucson, University of Arizona Cancer Center

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400