Year: 2019
Type: review
Abstract: Helicobacter pylori (H.pylori) is a Gram-negative bacterium with a number of virulence factors, such as cytotoxin-associated gene A, vacuolating cytotoxin A, its pathogenicity island, and lipopolysaccharide, which cause gastrointestinal diseases.Connexins function in gap junctional homeostasis, and their downregulation is closely related to gastric carcinogenesis.Investigations into H. pylori infection and the fine-tuning of connexins in cells or tissues have been reported in previous studies.Therefore, in this review, the potential mechanisms of H. pylori-induced gastric cancer through connexins are summarized in detail.
Institution: Third Xiangya Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2973733463