Year: 2008
Type: article
Abstract: MOTIVATION: Our goal was to understand why the PLIER algorithm performs so well given its derivation is based on a biologically implausible assumption. RESULTS: In spite of a non-intuitive assumption regarding the PM and MM errors made as part of the derivation for PLIER, the resulting probe level error function does capture the key characteristics of the ideal error function, assuming MM probes only measure non-specific binding and no signal.
Source: Cancer Informatics
Authors: Terry M. Therneau, Karla V. Ballman
Institution: Mayo Clinic
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,650
OpenAlex ID: W4253772226