Work

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

Year: 1984

Type: article

Abstract: shown to cleave DNA indirectly through their specific effect on the stabilization of a cleavable complex formed between mammalian DNA topoisomerase I1 and DNA (Nelson, E.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(18)90729-5

Authors: G L Chen, L Yang, T C Rowe, B D Halligan, K M Tewey, L F Liu

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Cancer therapeutics and mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W4253868125

FWCI: 5.355

Cites: 22

Cited by: 490

Related to: 10