Faculty Opinions recommendation of Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Year: 2010
Type: peer-review
Abstract: Chronic myelogenous leukemia (CML) can progress from an indolent chronic phase to an aggressive blast crisis phase 1 but the molecular basis of this transition remains poorly understood.Here we have used mouse models of CML 2 , 3 to show that disease progression is regulated by the Musashi-Numb signaling axis 4 , 5 .Specifically, we find that chronic phase is marked by high and blast crisis phase by low levels of Numb expression, and that ectopic expression of Numb promotes differentiation and impairs advanced phase disease in vivo.As a possible explanation for the decreased levels of Numb in blast crisis, we show that NUP98-HOXA9, an oncogene associated with blast crisis CML 6 , 7 , can trigger expression of the RNA binding protein Musashi2 Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html
Authors: Ross Levine, Omar Abdel-Wahab
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4254076425