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Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells

Year: 2016

Type: article

Abstract: (Molecular Cell 62, 848–861; June 16, 2016) In the original version of the above article, a recent publication and its findings had not been acknowledged. The online and print versions have now been corrected, and the corrected sentence reads “… but the importance of loss of H3K9me2 is not clear (Walter et al., 2016).” The full citation to the reference has been added to the reference list: Walter, M., Teissandier, A., Pérez-Palacios, R., Bourc’his, D. (2016). An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells. Elife 5. http://dx.doi.org/10.7554/eLife.11418 Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cellsvon Meyenn et al.Molecular CellMay 26, 2016In BriefGlobal demethylation during epigenetic reprogramming in preimplantation embryos, primordial germ cells, and naive embryonic stem cells is a consequence of impaired DNA methylation maintenance and synergistically regulated by a decrease in UHRF1 and H3K9me2 levels, while locus specific methylation maintenance is guided by specific recruitment of UHRF1 to H3K9me2/3. TET enzymes are dispensable for global DNA methylation reprogramming. Full-Text PDF Open Access

Source: Molecular Cell

DOI: 10.1016/j.molcel.2016.06.005