Work

siRNA carrying an (E)-vinylphosphonate moiety at the 5′ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2

Year: 2016

Type: article

Abstract: Nucl. Acids Res. (2016) doi: 10.1093/nar/gkw1171 Coordinates and structure factors for the human Argonaute-2-5΄-(E)-vinylphosphonate 2΄-O-methyl-uridine modified mrTTR guide RNA complex has been deposited in Protein Data Bank under accession code PDB 5T7B. The Authors apologise to the Readers for this omission.

Source: Nucleic Acids Research

DOI: 10.1093/nar/gkw1298