Year: 2015
Type: article
Abstract: (Cell 158, 1254–1269; September 11, 2014) Our paper reported that short-term expression of NANOG and KLF2 is sufficient to reset the state of pluripotency in human embryonic stem cells. Figure 7A, depicting colony formation after induced transgene expression, contains two identical images in which the same well is shown to represent both H9 and H1 cells (top row, images 4 and 5). This duplication arose during consolidation of images into the composite figure where the H9 well image was inadvertently inserted for both panels. The revised Figure 7 containing the correct H1 well image is shown below, and the figure has been corrected online. Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in HumanTakashima et al.CellSeptember 11, 2014In BriefInvoking the transcription factor circuitry that defines mouse embryonic stem cell identity converts human pluripotent cells to a more naive state, characterized by altered transcriptional and metabolic activity, absence of lineage priming, and global DNA hypomethylation. Full-Text PDF Open Access
Source: Cell
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $11,400
OpenAlex ID: W4254473479