Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
Year: 2020
Type: article
Study design: Observational Study
Abstract: Background : Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods : Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results : Among males, tumor (T1Gd) radius was a predictor of overall survival (HR=1.027, p=0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR=1.011, p<0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p=0.010 t-test), but tumor size was not correlated with female overall survival (p=0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p=0.004, F p=0.001, t-test). Conclusion : Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
Source: BMC Cancer
Authors: Paula Whitmire, Cassandra R. Rickertsen, Andrea Hawkins-Daarud, Eduardo Carrasco, Julia Lorence, Gustavo De Leon, Lee Curtin, Spencer Bayless, Kamala Clark-Swanson, Noah C. Peeri, Christina Corpuz, Christine Paula Lewis-de los Angeles, Bernard R. Bendok, Luis Gonzalez-Cuyar, Sujay Vora, Maciej Mrugala, Leland S. Hu, Lei Wang, Alyx Porter, Priya Kumthekar, Sandra K. Johnston, Kathleen M. Egan, Robert Gatenby, Peter Canoll, Joshua B. Rubin, Kristin R. Swanson
Institutions: Mayo Clinic, Arizona State University, University of Nottingham, Moffitt Cancer Center, Columbia University Irving Medical Center, Northwestern University, Mayo Clinic Hospital, University of Washington, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Columbia University, Washington University in St. Louis
Language: English
Subfield: Genetics (clinical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,390
Funder: James S. McDonnell Foundation
Award: G1495049103
OpenAlex ID: W3028590342