P4‐153: Elevated PiB precedes dementia in autosomal‐dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort
Year: 2012
Type: article
Study design: Observational Study
Abstract: DIAN (Dominantly Inherited Alzheimer's Network) is an international longitudinal study of autosomal dominant Alzheimer's Disease (ADAD). In addition to clinical, cognitive and psychometric testing, participants undergo serial multi-modal imaging. 120 participants representing a mix of non-carrier and carriers in both the presymptomatic and symptomatic stages of AD underwent PIB, FDG PET and MRI. Cohorts were determined based on genetic status, dementia severity (Clinical Dementia Rating, CDR), and estimated time to dementia onset (TDO, based on parental age of onset). All imaging exams were transformed and processed in a common atlas space using a combination of in-house software and FreeSurfer. Regions of interest were applied to volumetric T1-weighted MRI, FDG and PIB data. For each modality and cohort, a linear regression analysis was used to determine the effects of TDO on a vertex-by-vertex basis. Differences in PIB binding between carriers (M+) and non-carriers (M-) start to diverge up to 20 years prior to symptom onset (conversion to CDR 0.5). PIB retention in non-demented carriers were significantly different from the non-carrier cohort in the caudate, putamen and thalamus and in every cortical grey matter region (Figure 1). The first areas of significant amyloid deposition include the caudate, the occipital lobe, and the frontal lobe. Significant findings for grey matter volumes, cortical thickness, and FDG were limited to those carriers with dementia (CDR >=0.5) and did not reach significance in the pre-symptomatic population.
Source: Alzheimer s & Dementia
Authors: Tammie Benzinger, Tyler Blazey, Robert Koeppe, Clifford Jack, Marc Raichle, Yi Su, Abraham Snyder, Daniel Marcus, Keith Johnson, Reisa Sperling, John Ringman, Paul Thompson, Bernardino Ghetti, Andrew Saykin, Peter Schofield, Colin Masters, Christopher Rowe, Nick Fox, Adam Brickman, Richard Mayeux, Ralph Martins, Chester Mathis, William Klunk, Michael Weiner, Randall Bateman, Anne Fagan, Alison Goate, Nigel Cairns, Virginia Buckles, Krista Moulder, Victor Villemagne, John Morris
Institutions: Washington University in St. Louis, University of Michigan, Mayo Clinic, Brigham and Women's Hospital, Harvard University, University of California, Los Angeles, Indiana University Indianapolis, Neuroscience Research Australia, The University of Melbourne, University College London, Columbia University, Edith Cowan University, University of Pittsburgh, Austin Health
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4254792392