Work

Improved GPCR Ligands Based on Genetically Impossible Nanobody-Peptide Fusions

Year: 2019

Type: preprint

Abstract: Here we describe a new method for improving signalling potency and selectivity for suboptimal GPCR ligands through conjugation with receptor-targeting nanobodies

Source: ChemRxiv

DOI: 10.26434/chemrxiv.9619823

Authors: Ross Cheloha, Fabian A. Fischer, Andrew W. Woodham, Eileen Daley, Naomi Suminski, Thomas J. Gardella, Hidde L. Ploegh

Institutions: Boston Children's Hospital, Harvard University

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4254894369

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