Year: 2005
Type: article
Study design: Case Report
Abstract: A 56‐year‐old Asian woman presented with a 2‐year history of an asymptomatic lesion on her right cheek. On examination, she had an erythematous papule (Fig. 1). The patient had a good general health without previous history of any other cutaneous lesions. The initial clinical impression was basal cell carcinoma (BCC) and an excisional biopsy was performed. The pathology showed an unencapsulated intradermal lesion with multiple lobules and strands of basaloid cells within a desmoplastic stroma (Fig. 2a). Most of the lobules were limited by a peripheral palisade of basaloid cells and occupied by a lymphocyte‐predominant mixed cellular population. There were also large cells with a clear cytoplasm and large vesicular nuclei, many of which had one or two well‐defined nucleoli (Fig. 2b). We found neither mitotic figures nor nuclear atypia. In immunohistochemical studies, the epithelial cells were positive for cytokeratin and epithelial membrane antigen (EMA). The lymphocytes were positive for leucocyte common antigen (LCA) and UCHL‐1. The anti‐S‐100 protein labelled numerous intralobular dendritic cells, presumably Langerhans' cells. The intralobular large clear cells were positive for CD30 staining.
Authors: S. W. Son, Y. C. Kim, I. H. Kim
Institutions: Korea University, Ajou University
Language: English
Topic: Cancer and Skin Lesions
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4254926676