Year: 2009
Type: article
Abstract: Energy production by oxidative metabolism in kidney, stomach and heart, is primarily expended in establishing ion gradients to drive renal electrolyte homeostasis, gastric acid secretion, and cardiac muscle contraction, respectively. In addition to orchestrating transcriptional control of oxidative metabolism, the orphan nuclear receptor, Estrogen-Related Receptor gamma (ERRγ), coordinates expression of genes central to ion homeostasis in oxidative tissues. Renal, gastric and cardiac tissues subjected to genomic analysis of expression in perinatal ERRγ null mice revealed a characteristic dysregulation of genes involved in transport processes, exemplified by the voltage-gated potassium channel, Kcne2. Consistently, ERRγ null animals die during the first 72 h of life with elevated serum potassium, reductions in key gastric acid production markers, and cardiac arrhythmia with prolonged QT intervals. In addition, we find altered expression of several genes associated with hypertension in ERRγ null mice. These findings suggest a potential role for genetic polymorphisms at the ERRγ locus and ERRγ modulators in the etiology and treatment of renal, gastric, and cardiac dysfunction.
Source: Endocrine Reviews
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4254939014