Work

1: Cytotoxic T lymphocyte therapy for the treatment and prevention of adenovirus infection after stem cell transplant

Year: 2007

Type: article

Abstract: Adenoviruses (Adv) remain a major cause of mortality and morbidity in hematopoietic stem cell transplant (SCT) recipients. We evaluated the use of Adv-specific cytotoxic T lymphocytes (CTL) for prophylaxis and treatment of Adv infections post SCT. CTLs were initiated by infecting donor-derived mononuclear cells with the Ad5f35 vector (MOI 200 virus particles/cell). Responder cells were expanded by weekly restimulation with autologous EBV-transformed B lymphoblastoid cell lines (LCL) transduced with Ad5f35 at MOI of 500.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2006.12.002