A Role for Dopamine-Mediated Learning in the Pathophysiology and Treatment of Parkinson’s Disease
Year: 2014
Type: article
Abstract: (Cell Reports 2, 1747–1761; December 27, 2012) In the published version, Maria Sol Bernardez Sarria’s surname was misspelled as Bernandez. The corrected author list appears here, and the authors regret the error. A Role for Dopamine-Mediated Learning in the Pathophysiology and Treatment of Parkinson’s DiseaseBeeler et al.Cell ReportsDecember 13, 2012In BriefAlthough it has been demonstrated that dopamine denervation induces abnormalities in corticostriatal plasticity, the role this plays in Parkinson’s disease remains speculative. Beeler and colleagues show that dopamine blockade induces a D2-mediated aberrant learning that impairs future motor performance, even when dopamine is restored, suggesting abnormal corticostriatal plasticity is structurally encoding inappropriate inhibitory learning. Such aberrant learning may contribute significantly to the motor symptoms observed in Parkinson’s disease and represent an important target for the development of new therapeutics. Full-Text PDF Open Access
Source: Cell Reports
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,620
OpenAlex ID: W4255226316