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Catalytic, Enantioselective Synthesis of Allenyl Boronates

Year: 2018

Type: preprint

Abstract: A method to achieve enantioselective 1,4-hydroboration of terminal enynes to access allenyl boronates under CuH catalysis is described. The reaction typically proceeds in a highly stereoselective manner and tolerates an array of synthetically useful functional groups. The utility of the enantioenriched allenyl boronate products is demonstrated through several representative downstream derivatizations.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.5885203

Authors: De-Wei Gao, Yiyang Xiao, Mingyu Liu, Zhen Liu, Malkanthi K. Karunananda, Jason S. Chen, Keary Engle

Institution: Scripps Research Institute

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W4255316097

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Cited by: 1

Related to: 10