Work

Phospholipid Flippases

Year: 2006

Type: review

Abstract: Lipids in biological membranes are organized non-randomly across the bilayer. In eukaryotic cells, the cytoplasmic surface is enriched in anionic and primary amine-containing phospholipids (phosphoinositides (PIPn),2 phosphatidic acid, phosphatidylethanolamine (PE), phosphatidylserine (PS)), whereas the extracytoplasmic leaflet and the topologically equivalent lumenal surface of internal organelles are enriched in choline-containing phospholipids (phosphatidylcholine (PC) and sphingomyelin) and glycosphingolipids.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r600035200

Author: David L. Daleke

Institutions: Indiana University Bloomington, Indiana University School of Medicine, Indiana University

Language: English

Topic: Lipid Membrane Structure and Behavior

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: American Heart Association, National Institutes of Health, National Institute of General Medical Sciences