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Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

Year: 2018

Type: article

Abstract: (Cell Reports 22, 1522–1530; February 6, 2018) In the originally published version of this article, ALKs were incorrectly defined as “anaplastic lymphoma kinases,” whereas the correct definition is “activin-receptor-like kinases.” This definition has been corrected and now appears with the paper online. The authors regret this error. Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15Jones et al.Cell ReportsFebruary 06, 2018In BriefJones et al. find that high levels of GDF11 in mice induce symptoms of cachexia: skeletal muscle loss and anorexia. The anorexia is due to GDF11-dependent upregulation of GDF15. Downregulation of GDF11 in settings in which it exists at high levels is predicted to be beneficial. Full-Text PDF Open Access

Source: Cell Reports

DOI: 10.1016/j.celrep.2018.03.024

Authors: Juli E. Jones, Samuel M. Cadena, Chenguang Gong, Xiaomei Wang, Zhiping Chen, Sharon X. Wang, Chad Vickers, Hong Chen, Estelle Lach-Trifilieff, John R. Hadcock, David J. Glass

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620

OpenAlex ID: W4255867177

FWCI: 0.624

Cites:

Cited by: 13

Related to: 10